Getting hooked: Morphine tolerance
نویسندگان
چکیده
منابع مشابه
Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance.
Pain sensitivity reflects a balance between pain facilitatory and inhibitory systems. To characterize the relationships between these systems we examined the interactions between the analgesic effects of morphine and the anti-analgesic effects of the pro-inflammatory cytokine interleukin-1 (IL-1). We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, ...
متن کاملAcute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance.
The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems. Antinociception was detected via the hot water (52.5 d...
متن کاملConfessions of a Used Programming Language Salesman Getting the Masses Hooked on Haskell
For many years I had been fruitlessly trying to sell functional programming and Haskell to solve real world problems such as scripting and data-intensive three-tier distributed web applications. The lack of widespread adoption of Haskell is a real pity since functional programming concepts are key to curing many of the headaches that plague the majority of programmers, who today are forced to u...
متن کاملMechanisms underlying morphine analgesic tolerance and dependence.
The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanism...
متن کاملDelay of Morphine Tolerance by Palmitoylethanolamide
In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to the antinociceptive effect. The cellular and molecular mechanisms underlying morphine tolerance are complex and still unclear. Recently, the activation of glial cells and the release of glia-derived proinflammatory mediators have been suggested to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Biochemist
سال: 2007
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio02902012